The aim of the target product profiles (TPPs) for TPT is to identify the product attributes to be considered in developing the best, most suitable TB prevention treatments. These TPPs are expected to assist developers in aligning the characteristics of new treatment regimens and developers’ performance and operational targets with national requirements. This document describes priority and desirable regimen characteristics and outlines the minimal and optimal levels of acceptable performance for these attributes. In addition, it provides use case scenarios. The document is intended primarily for the pharmaceutical industry, academia, research institutions, product development partnerships, technical agencies, state and non-governmental bodies, civil society organizations and donors.